Plasma Pro-opiomelanocortin, Pro-adrenocorticotropin Hormone, and Pituitary Adenoma Size in Dogs with Cushing's Disease
نویسندگان
چکیده
منابع مشابه
Pro-opiomelanocortin Peptides in Mouse Pituitary Cells*
Pro-opiomelanocortin (POMC) is glycosylated and proteolytically cleaved to produce a number of smaller peptide hormones including adrenocorticotropic hormone (ACTH) and endorphin in mammalian pituitary and the mouse pituitary cell Line AtT-20/DI6,. When glycosylation of POMC is inhibited in AtT-20 cells with the drug tunicamycin, a 26,000-dalton protein appears in place of the glycosylated 29,0...
متن کاملPlasma Pituitary Prohormones and Pituitary Adenoma Size in Cushing’s Disease
Background: Hyperadrenocorticism in dogs is among the three most common endocrinopathies of dogs. Approximately 85% of dogs with spontaneous hyperadrenocorticism have pituitary-dependent hyperadrenocorticism (PDH). Pituitarydependent hyperadrenocorticism is due to an excessive secretion of adrenocorticotropic hormone (ACTH), usually by a pituitary microadenoma. However, up to 30% of PDH cases h...
متن کاملPro-opiomelanocortin mRNA size heterogeneity in ACTH-dependent Cushing's syndrome.
As an approach to understanding the abnormalities of pro-opiomelanocortin (POMC) gene regulation in human ACTH-secreting tumours, we have analysed the POMC mRNA content of nine such tumours using the Northern blot technique. Most of the tumours and normal human pituitary contained easily detectable quantities of POMC mRNA. The length of this message in most tumours was similar to, or slightly l...
متن کاملPituitary Radiotherapy for Cushings Disease
Background: The treatment of choice for Cushing’s disease is pituitary surgery. Second-line treatments include repeat pituitary surgery, radiation therapy, medical therapy, and bilateral adrenalectomy. The most used modalities to irradiate patients with Cushing’s disease include fractionated radiotherapy and single-dose Gamma Knife. We aim to review the efficacy and safety of radiotherapy in pa...
متن کاملProcessing of pro-opiomelanocortin-derived amidated joining peptide and glycine-extended precursor in monkey pituitary.
The molecular forms of proopiomelanocortin (POMC) derived amidated and C-terminal glycine-extended joining peptide from monkey (Macaca mulatta) pituitary were determined. The predominant forms of joining peptide found were the low molecular peptides POMC(76-105) and POMC(76-106), respectively. Significant amounts of N-terminally truncated POMC(78-105) and POMC(78-106) were also detected in the ...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 2005
ISSN: 0891-6640,1939-1676
DOI: 10.1111/j.1939-1676.2005.tb02653.x